Isabella Hofmann was born on December 11, 1958, in Chicago, Illinois, and is known for her versatile roles in television and film. She attended East Troy High School in Wisconsin and later studied at Columbia College Chicago.

Isabella Hofmann began her career with the comedy troupe The Second City before making her television debut in 1986. She is perhaps best known for her roles as Kate McCarron in the NBC sitcom "Dear John" (1988-1992), Megan Russert in "Homicide: Life on the Street" (1994-1997), and Dr. Renee Dunseith in "Providence" (2001-2002).

Her career spans several decades, and she has appeared in numerous television shows and movies. Some of her notable television credits include Meredith Cavanaugh on "JAG," Cecile Malone on "Beggars and Choosers," and Clarissa Stein in "The Flash" and "Legends of Tomorrow".

In film, she has appeared in movies such as "Tripwire" (1989), "Renaissance Man" (1994), and "The Princess Diaries 2: Royal Engagement" (2004).

Isabella Hofmann was married to actor Steven Memel from 1988 to 1994, and later had a long-term relationship with actor Daniel Baldwin from 1994 to 2005. Together, they have a son named Atticus, who was born in 1996 and has autism.