Natalie Talmadge was an American silent film actress born on April 29, 1896, in Brooklyn, New York. She was the middle sister of the famous Talmadge sisters, Norma and Constance, who were also actresses. She began her career in the early 1910s, appearing in small roles in films such as "Intolerance" (1916) and "The Isle of Conquest" (1919).

In 1921, she married actor Buster Keaton, and they had two sons together. Natalie appeared in Keaton's film "Our Hospitality" (1923), which was her final film role. After her marriage ended in 1933, Natalie largely retired from acting and lived a more private life.

She spent her later years in southern California and passed away on June 19, 1969, in Santa Monica.